MouseGastrulationData

Processed scRNAseq timecourse data along mouse gastrulation and early organogenesis

This package contains the processed 10X Genomics data from Pijuan-Sala et al. (2019), which were processed as described in the paper, and at its repository on Github. This includes gene counts, cell annotation, and reduced-dimension representations for the atlas, which are stored as a SingleCellExperiment object.

Processed scRNAseq data of chimeric embryos

Data for chimeric embryos, also generated for Pijuan-Sala et al. (2019), are available via this package, presented in a similar manner to the atlas data. These include the Tal1^-/-/wild-type and wild-type/wild-type chimaeras.

References

Blanca Pijuan-Sala^*, Jonathan A. Griffiths^*, Carolina Guibentif^*, Tom W. Hiscock, Wajid Jawaid, Fernando J. Calero-Nieto, Carla Mulas, Ximena Ibarra-Soria, Richard C.V. Tyser, Debbie Lee Lian Ho, Wolf Reik, Shankar Srinivas, Benjamin D. Simons, Jennifer Nichols, John C. Marioni, Berthold Göttgens. A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566, pp490-495 (2019).

Acknowledgement

Thanks to Aaron Lun, on whose work on the scRNAseq package this package is based.